Chemistry of α-oxoesters: a powerful tool for the synthesis of heterocycles

B Eftekhari-Sis, M Zirak - Chemical reviews, 2015 - ACS Publications
Heterocycles are an important class of organic compounds accounting for nearly one-third of
the past decade's publications, which are in the field of heterocyclic chemistry. In fact, two …

Recent advances in the Dimroth rearrangement: a valuable tool for the synthesis of heterocycles

H El Sayed, S Nadeem, MR Shah, Y El Kilany - Advances in Heterocyclic …, 2010 - Elsevier
Publisher Summary The Dimroth rearrangement (DR) is a translocation of two heteroatoms
in a heterocyclic system, with or without changing its ring structure. The conversion of a …

Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1, 2, 4] triazino [2, 3-c] quinazoline-6-yl) thio] acetamides

GG Berest, OY Voskoboynik, SI Kovalenko… - European journal of …, 2011 - Elsevier
In this paper the novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1, 2, 4] triazino [2, 3-c]
quinazoline-6-yl) thio] acetamides synthesis by aminolysis of activated by thionyl chloride or …

[HTML][HTML] Synthesis and Antimicrobial Activity of 6-Thioxo-6, 7-dihydro-2H-[1, 2, 4] triazino [2, 3-c]-quinazolin-2-one Derivatives

IS Nosulenko, OY Voskoboynik… - Scientia …, 2014 - pmc.ncbi.nlm.nih.gov
Abstract Potassium 8-R1-9-R2-10-R3-3-R-2-oxo-2H-[1, 2, 4] triazino [2, 3-c] quinazoline-6-
thiolates 2.1–2.26 were synthesized via cyclocondensation of 6-R-3-(3-R1-4-R2-5-R3 …

Hydrazinolysis of 3-R-[1,2,4]Triazino[2,3-c]quinazolin-2-ones. Synthetic and Theoretical Aspects

TY Sergeieva, OY Voskoboynik… - The Journal of …, 2014 - ACS Publications
It has been shown that heating of 3-R-[1, 2, 4] triazino [2, 3-c] quinazolin-2-ones with 5-fold
excess of hydrazine hydrate in propanol-2 gave the corresponding 3-(2-aminophenyl)-6-R …

Synthesis of spiro-fused (C5)-pyrazolino-(C6)-triazinones, a new heterocyclic system

AV Karpenko, SI Kovalenko, OV Shishkin - Tetrahedron, 2009 - Elsevier
Reaction of 4-hydrazinoquinazoline with 2, 4-diketoesters gives the corresponding 3-
acylmethyl-2H-[1, 2, 4] triazino [2, 3-c] quinazolin-2-ones in a one-step procedure via …

[HTML][HTML] Synthesis of new 6-{[ω-(dialkylamino (heterocyclyl) alkyl] thio}-3-R-2H-[1, 2, 4] triazino [2, 3-c] quinazoline-2-ones and evaluation of their anticancer and …

GG Berest, OY Voskoboynik… - Scientia …, 2012 - pmc.ncbi.nlm.nih.gov
Abstract Several novel 6-thio-3-R-2-oxo-2H-[1, 2, 4] triazino [2, 3-c] quinazoline-based
compounds containing an ω-(dialkylamino (heterocyclyl)] alkyl fragment were synthesized to …

Interaction of 3‐(2‐Aminophenyl)‐6‐R1‐1, 2, 4‐triazin‐5‐ones with Acylating Reagents: An Efficient Method for Preparation of 6‐Substituted 3‐R1‐2H‐[1, 2, 4] triazino …

AY Voskoboynik, DY Scorina… - Journal of …, 2016 - Wiley Online Library
The series of 6‐substituted 3‐R1‐2H‐[1, 2, 4] triazino [2, 3‐c] quinazolin‐2‐one was
prepared via condensation of 3‐(2‐aminophenyl)‐6‐R1‐1, 2, 4‐triazin‐5‐ones with …

[1,2,4]Triazino[2,3-с]quinazolines 1. Methods for the preparation and spectral characteristics of substituted 3-R1-6-R3-6,7-dihydro-2H-[1,2,4]triazino[2,3-с] …

OY Voskoboynik, OS Kolomoets, SI Kovalenko… - Chemistry of …, 2017 - Springer
A simple and effective method has been developed for the synthesis of previously unknown
substituted 3-R 1-6-R 3-6, 7-dihydro-2 H-[1, 2, 4] triazino-[2, 3-c] quinazolin-2-ones by …

Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity

OY Voskoboynik, SI Kovalenko… - Heterocyclic …, 2016 - degruyter.com
The synthesis and antitumor activity of substituted benzo [e][1, 2, 4] triazino [2, 3-c][1, 2, 3]
triazin-2-ones–novel electro-deficient tricyclic compounds–are described. These …