COVID-19-associated coagulopathy and disseminated intravascular coagulation

H Asakura, H Ogawa - International journal of hematology, 2021 - Springer
The pathology of coronavirus disease 2019 (COVID-19) is exacerbated by the progression
of thrombosis, and disseminated intravascular coagulation (DIC), and cytokine storms. The …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis

IM Tleyjeh, Z Kashour, M Damlaj, M Riaz… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

N Desai, A Neyaz, A Szabolcs, AR Shih… - Nature …, 2020 - nature.com
The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed …

IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19

T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

OJ McElvaney, GF Curley, S Rose-John… - The Lancet …, 2021 - thelancet.com
Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …

Latent class analysis reveals COVID-19–related acute respiratory distress syndrome subgroups with differential responses to corticosteroids

P Sinha, D Furfaro, MJ Cummings… - American journal of …, 2021 - atsjournals.org
Rationale: Two distinct subphenotypes have been identified in acute respiratory distress
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …

COVID-19: Advances in diagnostic tools, treatment strategies, and vaccine development

M Sreepadmanabh, AK Sahu, A Chande - Journal of biosciences, 2020 - Springer
An unprecedented worldwide spread of the SARS-CoV-2 has imposed severe challenges
on healthcare facilities and medical infrastructure. The global research community faces …

Intensive care management of patients with COVID-19: a practical approach

LA Hajjar, IBSS Costa, SI Rizk, B Biselli… - Annals of Intensive …, 2021 - Springer
Abstract SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is
responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the …

Severe acute respiratory syndrome coronavirus 2–induced immune activation and death of monocyte-derived human macrophages and dendritic cells

J Zheng, Y Wang, K Li, DK Meyerholz… - The Journal of …, 2021 - academic.oup.com
Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
patients and experimentally infected animals indicate a critical role for augmented …