Acute kidney injury (AKI) is common and is associated with serious short-and long-term
complications. Early diagnosis and identification of the underlying aetiology are essential to …

Background: Glomerular filtration rate (GFR) is routinely assessed by measuring the
concentrations of endogenous serum markers such as blood urea nitrogen and serum …

Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an
endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The …

Introduction 3. Discovery of the cystatin superfamily 4. Evolution and classification of the
cystatin superfamily 5. General properties of the cystatin superfamily 5.1. Type 1 cystatins …

Acute kidney injury (AKI) is strongly associated with increased morbidity and mortality in
critically ill patients. Efforts to change its clinical course have failed because clinically …

Cystatins comprise a large superfamily of related proteins with diverse biological activities.
They were initially characterised as inhibitors of lysosomal cysteine proteases, however, in …

Clinical biochemists have long known the analytical and clinical limitations of creatinine and
creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This …

Background: Cystatin C (CysC) may be a better marker of glomerular filtration rate (GFR)
than serum creatinine (SCr) level. Few studies derived CysC-based GFR prediction …

Background: Because of the limitations of serum creatinine as a marker of glomerular
filtration rate (GFR) in children, we assessed the diagnostic accuracy of the novel marker β …

Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal
function that could replace creatinine. Indeed, the concentration of cystatin C is mainly …