The Dihydrouridine landscape from tRNA to mRNA: A perspective on synthesis, structural impact and function

O Finet, C Yague-Sanz, F Marchand, D Hermand - RNA biology, 2022 - Taylor & Francis
The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine
by the Dus family of NADPH-dependent reductases and is typically found within the eponym …

Sequence-and Structure-Specific tRNA Dihydrouridylation by hDUS2

J Ji, NJ Yu, RE Kleiner - ACS Central Science, 2024 - ACS Publications
The post-transcriptional reduction of uridine to dihydrouridine (D) by dihydrouridine
synthase (DUS) enzymes is among the most ubiquitous transformations in RNA biology. D is …

An extended dsRBD is required for post-transcriptional modification in human tRNAs

C Bou-Nader, L Pecqueur, D Bregeon… - Nucleic acids …, 2015 - academic.oup.com
In tRNA, dihydrouridine is a conserved modified base generated by the post-transcriptional
reduction of uridine. Formation of dihydrouridine 20, located in the D-loop, is catalyzed by …

[PDF][PDF] From bacterial to human dihydrouridine synthase: automated structure determination

F Whelan, HT Jenkins, SC Griffiths… - … Section D: Biological …, 2015 - journals.iucr.org
The reduction of uridine to dihydrouridine at specific positions in tRNA is catalysed by
dihydrouridine synthase (Dus) enzymes. Increased expression of human dihydrouridine …

A minimal sequence motif drives selective tRNA dihydrouridylation by hDUS2

J Ji, NJ Yu, RE Kleiner - bioRxiv, 2023 - biorxiv.org
The post-transcriptional reduction of uridine to dihydrouridine (D) by dihydrouridine
synthase (DUS) enzymes is among the most ubiquitous transformations in RNA biology. D is …

[HTML][HTML] De novo crystal structure determination of double stranded RNA binding domain using only the sulfur anomalous diffraction in SAD phasing

BG Guimarães, B Golinelli-Pimpaneau - Current Research in Structural …, 2021 - Elsevier
Single-wavelength anomalous dispersion (SAD)-phasing using sulfur as the unique
anomalous scatterer is a powerful method to solve the phase problem in protein …

Regulation of Nitrate and Nitrite Assimilation in Paracoccus denitrificans at the Level of RNA

B Pinchbeck - 2016 - ueaeprints.uea.ac.uk
Paracoccus denitrificans, a model Alphaproteobacteria soil denitrifier, can grow solely on
nitrate or nitrite as inorganic nitrogen sources using a specialised cytoplasmic assimilatory …