Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Biomaterials have had an increasingly important role in recent decades, in biomedical
device design and the development of tissue engineering solutions for cell delivery, drug …

Human and bovine capillary endothelial cells were switched from growth to apoptosis by
using micropatterned substrates that contained extracellular matrix-coated adhesive islands …

(Hunter, 1998). RTKs play an important role in the control 1998; Jiang and Hunter, 1999).
Receptor dimerization is of most fundamental cellular processes including the further …

The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their
cellular responses by binding to and activating the different isoforms encoded by the four …

▪ Abstract Tyrosine phosphorylation is one of the key covalent modifications that occurs in
multicellular organisms as a result of intercellular communication during embryogenesis and …

Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in
common certain structural characteristics, and most of whom bind heparin avidly. Many …

The crystal structure of a dimeric 2: 2: 2 FGF: FGFR: heparin ternary complex at 3 Å
resolution has been determined. Within each 1: 1 FGF: FGFR complex, heparin makes …

Fibroblast growth factors (fgfs) are widely believed to activate their receptors by mediating
receptor dimerization. Here we show, however, that the FGF receptors form dimers in the …

When tissue loss disrupts normal architecture in higher vertebrate adult animals, the organ
fails to regenerate. Instead, repair proceeds as a fibroproliferative response that develops …