Next-generation vaccines that utilize T cells could potentially overcome the limitations of
current influenza vaccines that rely on antibodies to provide narrow subtype-specific …

To the Editor—We report the kinetics of immune responses in relation to clinical and
virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) …

Persistent and durable immunological memory forms the basis of any successful vaccination
protocol. Generation of pre-existing memory B cell and T cell pools is thus the key for …

An improved understanding of human T cell-mediated immunity in COVID-19 is important for
optimizing therapeutic and vaccine strategies. Experience with influenza shows that …

Peptide antigens bound to molecules encoded by the major histocompatibility complex
(MHC) and presented on the cell surface form the targets of T lymphocytes. This critical arm …

To better understand primary and recall T cell responses during coronavirus disease 2019
(COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome …

Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we
show circulating CD8+ T-cell profiles from patients hospitalized with avian H7N9, seasonal …

High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we
found that Australian First Nations peoples elicit effective immune responses to COVID-19 …

How innate and adaptive immune responses work in concert to resolve influenza disease is
yet to be fully investigated in one single study. Here, we utilize longitudinal samples from …

Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal
viral proteins confer broad protection against distinct strains of influenza A virus (IAV) …