Cardiac PET perfusion tracers: current status and future directions

J Maddahi, RRS Packard - Seminars in nuclear medicine, 2014 - Elsevier
PET myocardial perfusion imaging (MPI) is increasingly being used for noninvasive
detection and evaluation of coronary artery disease. However, the widespread use of PET …

Radiopharmaceutical tracers for cardiac imaging

O Manabe, T Kikuchi, AJHA Scholte… - Journal of Nuclear …, 2018 - Elsevier
Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide.
Nuclear myocardial perfusion imaging with either single-photon emission computed …

Added value of myocardial blood flow using 18F-flurpiridaz PET to diagnose coronary artery disease: The flurpiridaz 301 trial

JB Moody, A Poitrasson-Riviere, T Hagio… - Journal of Nuclear …, 2021 - Elsevier
Background 18 F-Flurpiridaz is a promising investigational radiotracer for PET myocardial
perfusion imaging with favorable properties for quantification of myocardial blood flow …

Imaging the myocardial ischemic cascade

AE Stillman, M Oudkerk, DA Bluemke… - The international journal …, 2018 - Springer
Non-invasive imaging plays a growing role in the diagnosis and management of ischemic
heart disease from its earliest manifestations of endothelial dysfunction to myocardial …

[HTML][HTML] Moving into the next era of PET myocardial perfusion imaging: introduction of novel 18F-labeled tracers

RA Werner, X Chen, SP Rowe, C Lapa… - … International Journal of …, 2019 - Springer
The heart failure epidemic continues to rise with coronary artery disease as one of its main
causes. Novel concepts for risk stratification to guide the referring cardiologist towards …

Myocardial viability: survival mechanisms and molecular imaging targets in acute and chronic ischemia

H Gewirtz, V Dilsizian - Circulation research, 2017 - Am Heart Assoc
Myocardial responses to acute ischemia/reperfusion and to chronic ischemic conditions
have been studied extensively at all levels of organization. These include subcellular (eg …

18F-flurpiridaz positron emission tomography segmental and territory myocardial blood flow metrics: incremental value beyond perfusion for coronary artery disease …

RRS Packard, JR Votaw, CD Cooke… - European Heart …, 2022 - academic.oup.com
Aims We determined the feasibility and diagnostic performance of segmental 18F-flurpiridaz
myocardial blood flow (MBF) measurement by positron emission tomography (PET) …

Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European …

R Sciagrà, A Passeri, J Bucerius, HJ Verberne… - European journal of …, 2016 - Springer
Until recently, PET was regarded as a luxurious way of performing myocardial perfusion
scintigraphy, with excellent image quality and diagnostic capabilities that hardly justified the …

[HTML][HTML] SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease

G Hendrikx, S Vöö, M Bauwens, MJ Post… - European Journal of …, 2016 - Springer
Purpose The extent of neovascularization determines the clinical outcome of coronary artery
disease and other occlusive cardiovascular disorders. Monitoring of neovascularization is …

The potential of F-18 flurpiridaz PET/CT myocardial perfusion imaging for precision imaging

KK Patel, A Singh, TM Bateman - Current Cardiology Reports, 2022 - Springer
Abstract Purpose of the Review Myocardial perfusion imaging (MPI) with single photon
emission computed tomography (SPECT) has been the main method for assessing patients …