The prevalence of obesity has increased worldwide over the past few decades. In 2013, the
prevalence of obesity exceeded the 50% of the adult population in some countries from …

Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Urate is the end-product of the purine metabolism in humans. The dominant source of urate
is endogenous purines and the remainder comes through diet. Approximately two thirds of …

In recent years, different subphenotypes of obesity have been described, including
metabolically healthy obesity (MHO), in which a proportion of obese individuals, despite …

Uric acid is the end product of purine metabolism in humans. High levels are causative in
gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of …

We conducted a scoping review to identify definitions of metabolically healthy obesity
(MHO), describe gaps in the literature, and establish a universal definition of MHO in …

Up to 30% of obese people do not display the “typical” metabolic obesity-associated
complications. For this group of patients, the term “metabolically healthy obese (MHO)” has …

Children with “metabolically healthy obesity”(MHO) are a distinct subgroup of youth with
obesity, who are less prone to the clustering of cardiometabolic risk factors. Although this …