Synthetic biology strategies for microbial biosynthesis of plant natural products

A Cravens, J Payne, CD Smolke - Nature communications, 2019 - nature.com
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

Development of halogenase enzymes for use in synthesis

J Latham, E Brandenburger, SA Shepherd… - Chemical …, 2018 - ACS Publications
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Phytostilbenes as agrochemicals: Biosynthesis, bioactivity, metabolic engineering and biotechnology

P Jeandet, A Vannozzi, E Sobarzo-Sánchez… - Natural product …, 2021 - pubs.rsc.org
Covering: 1976 to 2020. Although constituting a limited chemical family, phytostilbenes
represent an emblematic group of molecules among natural compounds. Ever since their …

Engineering plant secondary metabolism in microbial systems

ME Pyne, L Narcross, VJJ Martin - Plant physiology, 2019 - academic.oup.com
Engineering Plant Secondary Metabolism in Microbial Systems | Plant Physiology | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search Menu …

Biotechnological advances for improving natural pigment production: A state-of-the-art review

X Lyu, Y Lyu, H Yu, WN Chen, L Ye, R Yang - Bioresources and …, 2022 - Springer
In current years, natural pigments are facing a fast-growing global market due to the
increase of people's awareness of health and the discovery of novel pharmacological effects …

Retrosynthetic design of metabolic pathways to chemicals not found in nature

GM Lin, R Warden-Rothman, CA Voigt - Current Opinion in Systems …, 2019 - Elsevier
Biology produces a universe of chemicals whose precision and complexity is the envy of
chemists. Over the last 30 years, the expansive field of metabolic engineering has many …

Sustainable production of natural phenolics for functional food applications

R Mark, X Lyu, JJL Lee, R Parra-Saldívar… - Journal of Functional …, 2019 - Elsevier
Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

Building microbial factories for the production of aromatic amino acid pathway derivatives: from commodity chemicals to plant-sourced natural products

M Cao, M Gao, M Suastegui, Y Mei, Z Shao - Metabolic engineering, 2020 - Elsevier
The aromatic amino acid biosynthesis pathway, together with its downstream branches,
represents one of the most commercially valuable biosynthetic pathways, producing a …

Microbial production of value-added nutraceuticals

J Wang, S Guleria, MAG Koffas, Y Yan - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Nutraceuticals are health-promoting compounds of diverse structures and
origins.•Metabolic engineering enables microbes for value-added nutraceutical …

Natural sources and pharmacological properties of pinosylvin

S Bakrim, H Machate, T Benali, N Sahib, I Jaouadi… - Plants, 2022 - mdpi.com
Pinosylvin (3, 5-dihydroxy-trans-stilbene), a natural pre-infectious stilbenoid toxin, is a
terpenoid polyphenol compound principally found in the Vitaceae family in the heartwood of …