Toward neurosubtypes in autism

SJ Hong, JT Vogelstein, A Gozzi, BC Bernhardt… - Biological …, 2020 - Elsevier
There is a consensus that substantial heterogeneity underlies the neurobiology of autism
spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of …

Genetics of structural and functional brain changes in autism spectrum disorder

S Hashem, S Nisar, AA Bhat, SK Yadav… - Translational …, 2020 - nature.com
Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized
by social impairment and restricted interactive and communicative behaviors. It may occur …

An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

PN Alves, C Foulon, V Karolis, D Bzdok… - Communications …, 2019 - nature.com
The brain is constituted of multiple networks of functionally correlated brain areas, out of
which the default-mode network (DMN) is the largest. Most existing research into the DMN …

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

M Pagani, N Barsotti, A Bertero, S Trakoshis… - Nature …, 2021 - nature.com
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …

The human thalamus is an integrative hub for functional brain networks

K Hwang, MA Bertolero, WB Liu… - Journal of …, 2017 - Soc Neuroscience
The thalamus is globally connected with distributed cortical regions, yet the functional
significance of this extensive thalamocortical connectivity remains largely unknown. By …

The modular and integrative functional architecture of the human brain

MA Bertolero, BTT Yeo… - Proceedings of the …, 2015 - National Acad Sciences
Network-based analyses of brain imaging data consistently reveal distinct modules and
connector nodes with diverse global connectivity across the modules. How discrete the …

Unique spatiotemporal fMRI dynamics in the awake mouse brain

D Gutierrez-Barragan, NA Singh, FG Alvino, L Coletta… - Current biology, 2022 - cell.com
Human imaging studies have shown that spontaneous brain activity exhibits stereotypic
spatiotemporal reorganization in awake, conscious conditions with respect to minimally …

Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex

F Rocchi, C Canella, S Noei… - Nature …, 2022 - nature.com
While shaped and constrained by axonal connections, fMRI-based functional connectivity
reorganizes in response to varying interareal input or pathological perturbations. However …

Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

J Grandjean, C Canella, C Anckaerts, G Ayrancı… - Neuroimage, 2020 - Elsevier
Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer
the possibility to non-invasively probe whole-brain network dynamics and to investigate the …

Infraslow state fluctuations govern spontaneous fMRI network dynamics

D Gutierrez-Barragan, MA Basson, S Panzeri, A Gozzi - Current Biology, 2019 - cell.com
Spontaneous brain activity as assessed with resting-state fMRI exhibits rich spatiotemporal
structure. However, the principles by which brain-wide patterns of spontaneous fMRI activity …