Evidence from clinical and experimental studies indicates that macrophages promote solid-
tumour progression and metastasis. Macrophages are educated by the tumour …

It is increasingly proposed that reactive oxygen species (ROS) and reactive nitrogen species
(RNS) play a key role in human cancer development [1–6], especially as evidence is …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Several recent studies have identified nuclear factor-κB as a key modulator in driving
inflammation to cancers. Besides this transcription factor, essential in regulating …

A substantial body of evidence supports the conclusion that chronic inflammation can
predispose an individual to cancer, as demonstrated by the association between chronic …

In aerobic life, oxidative stress arises from both endogenous and exogenous sources.
Despite antioxidant defence mechanisms, cell damage from oxygen free radicals (OFR) is …

Carcinoma of the urinary bladder is the most common malignancy in the Middle East and
parts of Africa where schistosomiasis is a widespread problem. Much evidence supports the …

DNA damage plays a causal role in numerous human pathologies including cancer,
premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the …

Background Infection is one of the main risk factors for cancer. Objectives Epidemiology,
pathogenesis, and disease burden of infection-related cancers were reviewed by infectious …

Ulcerative colitis (UC) is a chronic inflammatory disease that produces reactive oxygen and
nitrogen species and increases the risk of colorectal cancer (CRC). The p53 tumor …