Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …

The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Background Intermittent treatment with sulfadoxine–pyrimethamine is widely recommended
for the prevention of malaria in pregnant women in Africa. However, with the spread of …

One hundred and twenty-five million women in malaria-endemic areas become pregnant
each year (see Dellicour et al. PLoS Med 7: e1000221 [2010]) and require protection from …

Background Intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin–
piperaquine is more effective than IPTp with sulfadoxine–pyrimethamine at reducing malaria …

Malaria remains one of the most preventable causes of adverse birth outcomes. Intermittent
preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine is used to prevent …

Background 2· 6 million stillbirths occur annually worldwide. The association between
malaria in pregnancy and stillbirth has yet to be comprehensively quantified. We aimed to …

Background Intermittent treatment with sulfadoxine–pyrimethamine, recommended for
prevention of malaria in pregnant women throughout sub-Saharan Africa, is threatened by …