Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection

L Pardo-López, M Soberón… - FEMS microbiology …, 2013 - academic.oup.com
Bacillus thuringiensis bacteria are insect pathogens that produce different Cry and Cyt toxins
to kill their hosts. Here we review the group of three-domain Cry (3d-Cry) toxins. Expression …

Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review

V Vachon, R Laprade, JL Schwartz - Journal of invertebrate pathology, 2012 - Elsevier
Bacillus thuringiensis (Bt) Cry toxins constitute the active ingredient in the most widely used
biological insecticides and insect-resistant transgenic crops. A clear understanding of their …

Diversity of Bacillus thuringiensis crystal toxins and mechanism of action

MJ Adang, N Crickmore, JL Jurat-Fuentes - Advances in insect physiology, 2014 - Elsevier
Parasporal crystals produced by Bacillus thuringiensis (Bt) bacteria are the main virulence
factors underlying Bt toxicity to insects. Parasporal crystals are composed primarily of Cry …

Engineering modified Bt toxins to counter insect resistance

M Soberón, L Pardo-López, I López, I Gómez… - Science, 2007 - science.org
The evolution of insect resistance threatens the effectiveness of Bacillus thuringiensis (Bt)
toxins that are widely used in sprays and transgenic crops. Resistance to Bt toxins in some …

[HTML][HTML] ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysis

Y Park, RM González-Martínez, G Navarro-Cerrillo… - BMC biology, 2014 - Springer
Background Relatively recent evidence indicates that ABCC2 transporters play a main role
in the mode of action of Bacillus thuringiensis (Bt) Cry1A-type proteins. Mapping of major …

[HTML][HTML] Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin

I Arenas, A Bravo, M Soberón, I Gómez - Journal of biological chemistry, 2010 - ASBMB
Cry toxins produced by Bacillus thuringiensis have been recognized as pore-forming toxins
whose primary action is to lyse midgut epithelial cells in their target insect. In the case of the …

[HTML][HTML] Shared Midgut Binding Sites for Cry1A.105, Cry1Aa, Cry1Ab, Cry1Ac and Cry1Fa Proteins from Bacillus thuringiensis in Two Important Corn Pests, Ostrinia nubilalis …

CS Hernández-Rodríguez, P Hernández-Martínez… - PloS one, 2013 - journals.plos.org
First generation of insect-protected transgenic corn (Bt-corn) was based on the expression of
Cry1Ab or Cry1Fa proteins. Currently, the trend is the combination of two or more genes …

[HTML][HTML] Bacillus thuringiensis: generalidades: Un acercamiento a su empleo en el biocontrol de insectos lepidópteros que son plagas agrícolas

DH Sauka, GB Benintende - Revista argentina de microbiología, 2008 - SciELO Argentina
Bacillus thuringiensis es el insecticida biológico más aplicado en el mundo y se utiliza para
controlar diversos insectos que afectan la agricultura, la actividad forestal y que transmiten …

[HTML][HTML] Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four Aminopeptidase N genes

S Herrero, T Gechev, PL Bakker, WJ Moar… - BMC genomics, 2005 - Springer
Abstract Background Insecticidal toxins from Bacillus thuringiensis bind to receptors on
midgut epithelial cells of susceptible insect larvae. Aminopeptidases N (APNs) from several …

Crystal structure of Bacillus thuringiensis Cry8Ea1: An insecticidal toxin toxic to underground pests, the larvae of Holotrichia parallela

S Guo, S Ye, Y Liu, L Wei, J Xue, H Wu, F Song… - Journal of structural …, 2009 - Elsevier
Crystal (Cry) proteins belong to an insect toxin family encoded and expressed by a variety of
Bacillus thuringiensis isolates, and are named due to their in vivo auto-crystallization …