Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …

Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

Heparanase enhances shedding of syndecan-1 (CD138), and high levels of heparanase
and shed syndecan-1 in the tumor microenvironment are associated with elevated …

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal
permselectivity of glomerular basement membrane (GBM) plays an important role in DN …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

Heparanase activity is strongly implicated in structural remodeling of the extracellular matrix,
a process which can lead to invasion by tumor cells. In addition, heparanase augments …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated
with colon cancer. Expression of the enzyme heparanase is clearly linked to colon …

Heparanase is an endo‐β‐d‐glucuronidase capable of cleaving heparan sulfate side chains
at a limited number of sites, yielding heparan sulfate fragments of still appreciable size …

Heparanase is the only known mammalian endoglycosidase capable of degrading heparan
sulfate glycosaminoglycan, both in extracellular space and within the cells. It is tightly …

Objective—Factors and mechanisms that activate macrophages in atherosclerotic plaques
are incompletely understood. We examined the capacity of heparanase to activate …