The bioavailability of drugs from oral formulations is influenced by many physiological
factors including gastrointestinal fluid composition, pH and dynamics, transit and motility …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

The experimental conditions that affect equilibrium solubility values measured by the
classical saturation shake-flask method have been examined, using hydrochlorothiazide as …

Measurement of drug solubility in various solvents is one of the key elements of compound
characterization during the whole discovery and development process. This review …

Supersaturating drug delivery systems (SDDS) hold the promise of enabling intestinal
absorption for difficult-to-formulate, poorly soluble drug candidates based on a design …

Abstract The Biopharmaceutical Classification System (BCS) has been a prognostic tool for
assessing the potential effects of formulation on the human drug oral bioavailability. When …

The significance of thermodynamic solubility in biopharmaceutical compound or drug
characterization as well as the importance of having methods that accurately establish it …

The purposes of the review are to: a) Provide a comprehensible introduction of the-state-
ofthe-art sciences of solubility and dissolution, b) introduce typical technologies to assess …

Sažetak This commentary addresses data quality in equilibrium solubility measurement in
aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to …

The introduction of the biopharmaceutics drug classification system (Biopharmaceutics
Classification System (BCS)), in 1995, provided a simple way to describe the …