Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases

Y Tai, Q Wang, H Korner, L Zhang, W Wei - Frontiers in pharmacology, 2018 - frontiersin.org
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects
the progression of the immune response including autoimmune diseases. Antigen …

Development and functional specialization of CD103+ dendritic cells

ML Del Rio, G Bernhardt… - Immunological …, 2010 - Wiley Online Library
CD103 (αE) integrin expression distinguishes a population of dendritic cells (DCs) that can
be found in many if not all lymphoid and non‐lymphoid organs. CD103+ DCs display distinct …

Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node

G Hintzen, L Ohl, ML del Rio… - The Journal of …, 2006 - journals.aai.org
Allergic airway diseases such as asthma are caused by a failure of the immune system to
induce tolerance against environmental Ags. The underlying molecular and cellular …

Differential intrasplenic migration of dendritic cell subsets tailors adaptive immunity

S Calabro, D Liu, A Gallman, MSL Nascimento, Z Yu… - Cell reports, 2016 - cell.com
Evidence suggests that distinct splenic dendritic cell (DC) subsets activate either CD4+ or
CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen …

Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design

MA Swartz, JA Hubbell, ST Reddy - Seminars in immunology, 2008 - Elsevier
The slow interstitial flow that drains fluid from the blood capillaries into the lymphatic
capillaries provides transport of macromolecular nutrients to cells in the interstitium. We …

Physiology of chemokines in the cancer microenvironment

D Drouillard, BT Craig… - American Journal of …, 2023 - journals.physiology.org
Chemokines are chemotactic cytokines whose canonical functions govern movement of
receptor-expressing cells along chemical gradients. Chemokines are a physiological system …

Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function

A Del Prete, WH Shao, S Mitola, G Santoro, S Sozzani… - Blood, 2007 - ashpublications.org
Trafficking of dendritic cells (DCs) to peripheral tissues and to secondary lymphoid organs
depends on chemokines and lipid mediators. Here, we show that bone marrow–derived …

Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein

S de Noronha, S Hardy, J Sinclair, MP Blundell, J Strid… - Blood, 2005 - ashpublications.org
Regulated migration and spatial localization of dendritic cells (DCs) are critical events
during the initiation of physiologic immune responses and maintenance of tolerance. Here …

Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes

Z Alraies, CA Rivera, MG Delgado, D Sanséau… - Nature …, 2024 - nature.com
Immune cells experience large cell shape changes during environmental patrolling because
of the physical constraints that they encounter while migrating through tissues. These cells …

Compartmentalization of dendritic cell and T‐cell interactions in the lymph node: anatomy of T‐cell fate decisions

B León, FE Lund - Immunological reviews, 2019 - Wiley Online Library
Upon receiving cognate and co‐stimulatory priming signals from antigen (Ag)‐presenting
dendritic cells (DCs) in secondary lymphoid tissues, naïve CD4+ T cells differentiate into …