Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects
the progression of the immune response including autoimmune diseases. Antigen …
the progression of the immune response including autoimmune diseases. Antigen …
Development and functional specialization of CD103+ dendritic cells
ML Del Rio, G Bernhardt… - Immunological …, 2010 - Wiley Online Library
CD103 (αE) integrin expression distinguishes a population of dendritic cells (DCs) that can
be found in many if not all lymphoid and non‐lymphoid organs. CD103+ DCs display distinct …
be found in many if not all lymphoid and non‐lymphoid organs. CD103+ DCs display distinct …
Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node
G Hintzen, L Ohl, ML del Rio… - The Journal of …, 2006 - journals.aai.org
Allergic airway diseases such as asthma are caused by a failure of the immune system to
induce tolerance against environmental Ags. The underlying molecular and cellular …
induce tolerance against environmental Ags. The underlying molecular and cellular …
Differential intrasplenic migration of dendritic cell subsets tailors adaptive immunity
Evidence suggests that distinct splenic dendritic cell (DC) subsets activate either CD4+ or
CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen …
CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen …
Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design
The slow interstitial flow that drains fluid from the blood capillaries into the lymphatic
capillaries provides transport of macromolecular nutrients to cells in the interstitium. We …
capillaries provides transport of macromolecular nutrients to cells in the interstitium. We …
Physiology of chemokines in the cancer microenvironment
D Drouillard, BT Craig… - American Journal of …, 2023 - journals.physiology.org
Chemokines are chemotactic cytokines whose canonical functions govern movement of
receptor-expressing cells along chemical gradients. Chemokines are a physiological system …
receptor-expressing cells along chemical gradients. Chemokines are a physiological system …
Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function
Trafficking of dendritic cells (DCs) to peripheral tissues and to secondary lymphoid organs
depends on chemokines and lipid mediators. Here, we show that bone marrow–derived …
depends on chemokines and lipid mediators. Here, we show that bone marrow–derived …
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein
S de Noronha, S Hardy, J Sinclair, MP Blundell, J Strid… - Blood, 2005 - ashpublications.org
Regulated migration and spatial localization of dendritic cells (DCs) are critical events
during the initiation of physiologic immune responses and maintenance of tolerance. Here …
during the initiation of physiologic immune responses and maintenance of tolerance. Here …
Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Z Alraies, CA Rivera, MG Delgado, D Sanséau… - Nature …, 2024 - nature.com
Immune cells experience large cell shape changes during environmental patrolling because
of the physical constraints that they encounter while migrating through tissues. These cells …
of the physical constraints that they encounter while migrating through tissues. These cells …
Compartmentalization of dendritic cell and T‐cell interactions in the lymph node: anatomy of T‐cell fate decisions
B León, FE Lund - Immunological reviews, 2019 - Wiley Online Library
Upon receiving cognate and co‐stimulatory priming signals from antigen (Ag)‐presenting
dendritic cells (DCs) in secondary lymphoid tissues, naïve CD4+ T cells differentiate into …
dendritic cells (DCs) in secondary lymphoid tissues, naïve CD4+ T cells differentiate into …