Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …

The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the
identification of therapeutic targets, clinical research, and advancing patient care. Because …

Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …

Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of
somatic glioma driving alterations and suboptimal disease classification. We defined the …

We report a comprehensive molecular characterization of pheochromocytomas and
paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that …