This mini-review discusses agent-based models as modeling techniques for studying
pattern formation of multi-cellular systems in biology. We introduce and compare different …

The growth and dynamics of multicellular tissues involve tightly regulated and coordinated
morphogenetic cell behaviors, such as shape changes, movement, and division, which are …

The Hybrid Automata Library (HAL) is a Java Library developed for use in mathematical
oncology modeling. It is made of simple, efficient, generic components that can be used to …

Organoids are engineered three-dimensional tissue cultures derived from stem cells and
capable of self-renewal and self-organization into a variety of progenitors and differentiated …

Cells are fundamental units of life, constantly interacting and evolving as dynamical systems.
While recent spatial multi-omics can quantitate individual cells' characteristics and …

Ubiquitous in embryonic development, tissue fusion is of interest to tissue engineers who
use tissue spheroids or organoids as building blocks of three-dimensional (3D) multicellular …

Multicellular aggregates are known to exhibit liquid-like properties. The fusion process of
two cell aggregates is commonly studied as the coalescence of two viscous drops. However …

Pluripotent stem cells, in the recent years, have been demonstrated to mimic different
aspects of metazoan embryonic development in vitro. This has led to the establishment of …

In recent years, multi–cellular models, where cells are represented as individual interacting
entities, are becoming ever popular. This has led to a proliferation of novel methods and …

Reverse engineering mechanistic gene regulatory network (GRN) models with a specific
dynamic spatial behavior is an inverse problem without analytical solutions in general …