19F NMR applications in chemical biology
Although fluorine plays only a minor role in biology, its physicochemical properties have
proven incredibly useful in the design of analogues of biologically important molecules …
proven incredibly useful in the design of analogues of biologically important molecules …
Natural and engineered biosynthesis of fluorinated natural products
MC Walker, MCY Chang - Chemical Society Reviews, 2014 - pubs.rsc.org
Both natural products and synthetic organofluorines play important roles in the discovery
and design of pharmaceuticals. The combination of these two classes of molecules has the …
and design of pharmaceuticals. The combination of these two classes of molecules has the …
Fluorotelomer alcohol biodegradation yields poly-and perfluorinated acids
MJA Dinglasan, Y Ye, EA Edwards… - … science & technology, 2004 - ACS Publications
The widespread detection of environmentally persistent perfluorinated acids (PFCAs) such
as perfluorooctanoic acid (PFOA) and its longer chained homologues (C9> C15) in biota …
as perfluorooctanoic acid (PFOA) and its longer chained homologues (C9> C15) in biota …
Herceptin acts as an anti-angiogenic cocktail
Y Izumi, L Xu, E Di Tomaso, D Fukumura, RK Jain - Nature, 2002 - nature.com
Malignant tumours secrete factors that enable them to commandeer their own blood supply
(angiogenesis), and blocking the action of these factors can inhibit tumour growth. But …
(angiogenesis), and blocking the action of these factors can inhibit tumour growth. But …
[HTML][HTML] Biosynthesis of an organofluorine molecule
Although fluorine in the form of fluoride minerals is the most abundant halogen in the Earth's
crust, only 12 naturally occurring organofluorine compounds have so far been found, and …
crust, only 12 naturally occurring organofluorine compounds have so far been found, and …
Natural organohalogens: a new frontier for medicinal agents?
GW Gribble - Journal of Chemical Education, 2004 - ACS Publications
More than 4000 naturally occurring organohalogen compounds are known. These include a
relatively small number of abiogenic organohalogens from volcanoes, forest fires …
relatively small number of abiogenic organohalogens from volcanoes, forest fires …
[HTML][HTML] Fluoroacetate in plants-a review of its distribution, toxicity to livestock and microbial detoxification
Fluoroacetate producing plants grow worldwide and it is believed they produce this toxic
compound as a defence mechanism against grazing by herbivores. Ingestion by livestock …
compound as a defence mechanism against grazing by herbivores. Ingestion by livestock …
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya
Organofluorine compounds are rare in Nature, with only a handful known to be produced by
some species of plant and two microorganisms. Consequently, the mechanism of enzymatic …
some species of plant and two microorganisms. Consequently, the mechanism of enzymatic …
The rare fluorinated natural products and biotechnological prospects for fluorine enzymology
KKJ Chan, D O'Hagan - Methods in enzymology, 2012 - Elsevier
Nature has hardly evolved a biochemistry of fluorine although there is a low-level
occurrence of fluoroacetate found in selected tropical and subtropical plants. This …
occurrence of fluoroacetate found in selected tropical and subtropical plants. This …
Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya
H Deng, D O'Hagan, C Schaffrath - Natural product reports, 2004 - pubs.rsc.org
Covering: the literature from 2000–2004 This review outlines the recent developments in
uncovering the enzymes and intermediates involved in fluorometabolite biosynthesis in the …
uncovering the enzymes and intermediates involved in fluorometabolite biosynthesis in the …