Although fluorine plays only a minor role in biology, its physicochemical properties have
proven incredibly useful in the design of analogues of biologically important molecules …

Both natural products and synthetic organofluorines play important roles in the discovery
and design of pharmaceuticals. The combination of these two classes of molecules has the …

The widespread detection of environmentally persistent perfluorinated acids (PFCAs) such
as perfluorooctanoic acid (PFOA) and its longer chained homologues (C9> C15) in biota …

Malignant tumours secrete factors that enable them to commandeer their own blood supply
(angiogenesis), and blocking the action of these factors can inhibit tumour growth. But …

Although fluorine in the form of fluoride minerals is the most abundant halogen in the Earth's
crust, only 12 naturally occurring organofluorine compounds have so far been found, and …

More than 4000 naturally occurring organohalogen compounds are known. These include a
relatively small number of abiogenic organohalogens from volcanoes, forest fires …

Fluoroacetate producing plants grow worldwide and it is believed they produce this toxic
compound as a defence mechanism against grazing by herbivores. Ingestion by livestock …

Organofluorine compounds are rare in Nature, with only a handful known to be produced by
some species of plant and two microorganisms. Consequently, the mechanism of enzymatic …

Nature has hardly evolved a biochemistry of fluorine although there is a low-level
occurrence of fluoroacetate found in selected tropical and subtropical plants. This …

Covering: the literature from 2000–2004 This review outlines the recent developments in
uncovering the enzymes and intermediates involved in fluorometabolite biosynthesis in the …