Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures.
Approximately one-third of epilepsy patients will not achieve seizure freedom with medical …

A burgeoning literature documents the confluence of ovarian steroids and central
serotonergic systems in the injunction of epileptic seizures and epileptogenesis. Estrogen …

Key points Sudden unexpected death in epilepsy is the leading cause of death in patients
with refractory epilepsy. Respiratory and cardiac impairment induced by a seizure have …

Abstract Observations in witnessed Sudden Unexpected Death in Epilepsy (SUDEP)
suggest that a fatal breakdown of the central autonomic control could play a major role in …

In this paper, we review the experience with fenfluramine in epileptic and other paroxysmal
disorders. Since the best available data are from the treatment of Dravet syndrome, we will …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients
with refractory epilepsy. A proposed risk marker for SUDEP is the duration of post-ictal …

Epilepsy accounts for a significant portion of the disease burden worldwide and high
mortality especially for those that epilepsy does not remit. With the current explosion in …

The vesicular neurotransmitter transporters (VNTs) are small proteins responsible for
packing synaptic vesicles with neurotransmitters thereby determining the amount of …

Status epilepticus (SE) is a life‐threatening neurologic disorder that can be as both cause
and consequence of neuroinflammation. In addition to previous reports on anti‐inflammatory …

Background and Purpose Two of the most relevant unmet needs in epilepsy are represented
by the development of disease‐modifying drugs able to affect epileptogenesis and/or the …