Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

During blood stage Plasmodium falciparum infection, merozoites invade uninfected
erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand …

Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

Abstract Apical membrane antigen 1 (AMA1) is a key malaria vaccine candidate and target
of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form …

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is
caused by the intracellular parasite Plasmodium. However, increased resistance to ACT …

All the symptoms and pathology of malaria are caused by the intraerythrocytic stages of the
Plasmodium parasite life cycle. Because Plasmodium parasites cannot replicate outside a …

Regulated exocytosis by secretory organelles is important for malaria parasite invasion and
egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are …

Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells.
Invasion is a conserved process that relies on the timely and spatially controlled exocytosis …

Apicomplexa exhibit a unique form of substrate-dependent gliding motility central for host
cell invasion and parasite dissemination. Gliding is powered by rearward translocation of …