Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …

Epigenome-wide association studies (EWAS) hold promise for the detection of new
regulatory mechanisms that may be susceptible to modification by environmental and …

Motivation: Recently there has been increasing interest in the effects of cell mixture on the
measurement of DNA methylation, specifically the extent to which small perturbations in cell …

The potential influence of underlying differences in relative leukocyte distributions in studies
involving blood-based profiling of DNA methylation is well recognized and has prompted …

The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary
prevention strategies are urgently required. The ideal risk-predictive test should: integrate …

Background Confounding due to cellular heterogeneity represents one of the foremost
challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical …

Multiple studies have investigated global DNA methylation profiles and gene-specific DNA
methylation in blood-based DNA to develop powerful screening markers for cancer. This …

Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues
are ensembles of cells that may each have their own epigenetic profile, and therefore inter …

Long-term exposure to air pollution has been associated with several adverse health effects
including cardiovascular, respiratory diseases and cancers. However, underlying molecular …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …