Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …

Cytosolic lipid droplets (LDs) are the main storage organelles for metabolic energy in most
cells. They are unusual organelles that are bounded by a phospholipid monolayer and …

To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …

The time step of atomistic molecular dynamics (MD) simulations is determined by the fastest
motions in the system and is typically limited to 2 fs. An increasingly popular approach is to …

In the age of failing small-molecule antibiotics, tapping the near-infinite structural and
chemical repertoire of antimicrobial peptides (AMPs) offers one of the most promising routes …

Sensing membrane curvature allows fine-tuning of complex reactions that occur at the
surface of membrane-bound organelles. One of the most sensitive membrane curvature …

Conspectus Ever since the first molecular mechanics computer simulations of biological
molecules became possible, there has been the dream to study all complex biological …

Many antimicrobial peptides (AMPs) selectively target and form pores in microbial
membranes. However, the mechanisms of membrane targeting, pore formation and function …

The determination of membrane protein (MP) structures has always trailed that of soluble
proteins due to difficulties in their overexpression, reconstitution into membrane mimetics …