Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Engineered tissues can be used to model human pathophysiology and test the efficacy and
safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered …

The gut microbiota and their metabolites could play an important role in health and diseases
of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome …

Women's health concerns are generally underrepresented in basic and translational
research, but reproductive health in particular has been hampered by a lack of …

Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …

Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

For the past century, experimental data obtained from animal studies have been required by
reviewers of scientific articles and grant applications to validate the physiological relevance …

Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …

The gut microbiota is implicated in immune system functions. Regulation of the metabolic
processes occurring in immune cells is crucial for the maintenance of homeostasis and …