Patients developing posttransplant antibodies against HLA and non-HLA antigens
expressed by the endothelium of the graft undergo more frequent episodes of rejection and …

Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders.
Unfortunately, chronic lung allograft dysfunction (CLAD), most commonly manifest as …

BACKGROUND: Because the development of donor-specific anti-human leukocyte antigen
(HLA) antibodies (DSA) after lung transplantation has been associated with acute and …

Background Bronchiolitis obliterans syndrome (BOS) is the major cause of late graft failure
after lung transplantation. The objective was to determine whether de novo donor human …

Outcomes after lung transplantation are markedly inferior to those after other solid organ
transplants. A better understanding of cellular and molecular mechanisms contributing to …

Anti-HLA Abs have been shown to contribute to the process of transplant vasculopathy by
binding to HLA class I molecules expressed by the endothelial and smooth muscle cells of …

Recent studies strongly suggest an increasing role for immune responses against self-
antigens (Ags) which are not encoded by the major histocompatibility complex in the …

Lung transplantation has become an established therapeutic option for a variety of end-
stage lung diseases. Technical advances in graft procurement, implantation, perioperative …

Obliterative bronchiolitis (OB)(formerly termed bronchiolitis obliterans), is a rare fibrotic
disorder involving terminal and respiratory bronchioles. The term constrictive bronchiolitis is …

Retrospective studies of angiotensin II type 1 receptor antibodies (AT1R-Ab) and anti-
endothelial cell antibodies (AECA) have linked these antibodies to allograft injury. Because …