Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly
a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy …

Melanocyte development provides an excellent model for studying more complex
developmental processes. Melanocytes have an apparently simple aetiology, differentiating …

Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

Immunotherapies, signal transduction inhibitors and chemotherapies can successfully
achieve remissions in advanced stage cancer patients, but durable responses are rare …

Limb regeneration is a frontier in biomedical science. Identifying triggers of innate
morphogenetic responses in vivo to induce the growth of healthy patterned tissue would …

The skin and its appendages constitute the largest organ of the body. Its stratified epithelia
offer protection from environmental stresses such as dehydration, irradiation, mechanical …

Establishment of shape during embryonic development, and the maintenance of shape
against injury or tumorigenesis, requires constant coordination of cell behaviors toward the …

Deregulation of signaling pathways that control differentiation, expansion and migration of
neural crest-derived melanoblasts during normal development contributes also to …

Skin pigmentation is one of the most overt human physical traits with consequences on
susceptibility to skin cancer. The variations in skin pigmentation are dependent on …

It has not previously been possible to live image the earliest interactions between the host
environment and oncogene-transformed cells as they initiate formation of cancers within an …