Corticosteroids have numerous applications in treating inflammation and diseases of
immune function based on their significant anti-inflammatory and immunosuppressive …

The term “precision medicine” has become very popular over recent years, fuelled by
scientific as well as political perspectives. Despite its popularity, its exact meaning, and how …

Systemic corticosteroid use to manage uncontrolled asthma and its associated healthcare
burden may account for important health-related adverse effects. We conducted a systematic …

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society …

Reduced responsiveness to the anti-inflammatory effects of corticosteroids is a major barrier
to effective management of asthma in smokers and patients with severe asthma and in the …

Importance Asthma affects about 7.5% of the adult population. Evidence-based diagnosis,
monitoring, and treatment can improve functioning and quality of life in adult patients with …

Asthma phenotypes have been developed to address the complexities of the disease.
However, owing to a lack of longitudinal studies, little is known about the onset as well as …

Glucocorticoids regulate many physiological processes and have an essential role in the
systemic response to stress. For example, gene transcription is modulated by the …

Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However …