Through their unique and specific interactions with various metal ions, naturally occurring
proteins control structures and functions of many biological processes and functions in …

The major endoproteolytic processing enzymes of the secretory pathway are the subtilisin-
like proprotein convertases (SPCs). Furin (SPC1) has emerged as one of the major …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …

Many cellular processes, including embryogenesis (1–4), gene expression (5), cell cycle (6),
programmed cell death (7), intracellular protein targeting (8) and endocrine/neural functions …

The important role of furin in the proteolytic activation of many pathogenic molecules has
made this endoprotease a target for the development of potent and selective antiproteolytic …

Five novel peptides were identified in the brains of mice lacking active carboxypeptidase E,
a neuropeptide-processing enzyme. These peptides are produced from a single precursor …

Limited endoproteolysis of biologically inactive polypeptide precursors is a general
mechanism generating a diversity of biologically active peptides and proteins in all …

Cell-cell interaction is a feature of even the simplest biological systems, as shown by the
exchange of genetic material between bacteria and by mating in unicellular eukaryotes such …

Limited proteolysis of most large protein precursors is carried out in vivo by the subtilisin-like
pro-protein convertases. Many important biological processes such as peptide hormone …

7B2 is an acidic protein residing in the secretory granules of neuroendocrine cells. Its
sequence has been elucidated in many phyla and species. It shows high similarity among …