CaImAn an open source tool for scalable calcium imaging data analysis

A Giovannucci, J Friedrich, P Gunn, J Kalfon, BL Brown… - elife, 2019 - elifesciences.org
Advances in fluorescence microscopy enable monitoring larger brain areas in-vivo with finer
time resolution. The resulting data rates require reproducible analysis pipelines that are …

Twitches, blinks, and fidgets: important generators of ongoing neural activity

PJ Drew, AT Winder, Q Zhang - The Neuroscientist, 2019 - journals.sagepub.com
Animals and humans continuously engage in small, spontaneous motor actions, such as
blinking, whisking, and postural adjustments (“fidgeting”). These movements are …

Cortical sensory processing across motivational states during goal-directed behavior

G Matteucci, M Guyoton, JM Mayrhofer, M Auffret… - Neuron, 2022 - cell.com
Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is
unclear how altered neuronal sensory representations in these states relate to task …

Stress and behavioral correlates in the head-fixed method: stress measurements, habituation dynamics, locomotion, and motor-skill learning in mice

K Juczewski, JA Koussa, AJ Kesner, JO Lee… - Scientific reports, 2020 - nature.com
Manual restriction of head movement, or head-fixation, of awake rodents allows for
sophisticated investigation of neural circuits in vivo, that would otherwise be impossible in …

Computer methods for automatic locomotion and gesture tracking in mice and small animals for neuroscience applications: a survey

W Abbas, D Masip Rodo - Sensors, 2019 - mdpi.com
Neuroscience has traditionally relied on manually observing laboratory animals in controlled
environments. Researchers usually record animals behaving freely or in a restrained …

Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability

F Bertan, L Wischhof, L Sosulina, M Mittag… - Cell Death & …, 2020 - nature.com
Dendritic spines are postsynaptic domains that shape structural and functional properties of
neurons. Upon neuronal activity, Ca2+ transients trigger signaling cascades that determine …

Real-time closed-loop feedback in behavioral time scales using DeepLabCut

K Sehara, P Zimmer-Harwood, ME Larkum… - eneuro, 2021 - eneuro.org
Computer vision approaches have made significant inroads into offline tracking of behavior
and estimating animal poses. In particular, because of their versatility, deep-learning …

High‐throughput analysis of vocalizations reveals sex‐specific changes in Fmr1 mutant pups

SO Nolan, SL Hodges, JN Lugo - Genes, Brain and Behavior, 2020 - Wiley Online Library
There have been several reports that individuals with Fragile X syndrome (FXS) and animal
models of FXS have communication deficits. The present study utilized two different call …

Leptin deficiency-caused behavioral change–A comparative analysis using EthoVision and DeepLabCut

D Bühler, N Power Guerra, L Müller… - Frontiers in …, 2023 - frontiersin.org
Introduction Obese rodents eg, the leptin-deficient (ob/ob) mouse exhibit remarkable
behavioral changes and are therefore ideal models for evaluating mental disorders resulting …

Deficits in cerebellum-dependent learning and cerebellar morphology in male and female BTBR autism model mice

EA Kiffmeyer, JA Cosgrove, JK Siganos, HE Bien… - NeuroSci, 2022 - mdpi.com
Recently, there has been increased interest in the role of the cerebellum in autism spectrum
disorder (ASD). To better understand the pathophysiological role of the cerebellum in ASD, it …