Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Signalling between cells of the neurovascular unit, or neurovascular coupling, is essential to
match local blood flow with neuronal activity. Pericytes interact with endothelial cells and …

Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Diabetic retinopathy remains a relevant clinical problem. In parallel with diagnostic and
therapeutic improvements, the role of glycaemia and reactive metabolites causing cell stress …

Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of
biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …