Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

The near completeness of human chromosome sequences is facilitating accurate
characterization and assessment of all classes of genomic variation. Particularly, using the …

We have conducted a comprehensive search for conserved elements in vertebrate
genomes, using genome-wide multiple alignments of five vertebrate species (human …

PAL2NAL is a web server that constructs a multiple codon alignment from the corresponding
aligned protein sequences. Such codon alignments can be used to evaluate the type and …

The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major
force for human evolutionary selection, but surprisingly few other polymorphisms have been …

Acute necrotizing encephalopathy (ANE) is a rapidly progressive encephalopathy that can
occur in otherwise healthy children after common viral infections such as influenza and …

Background Growth and meat production traits are significant economic traits in sheep. The
aim of the study is to identify candidate genes affecting growth and meat production traits at …

During infection by invasive bacteria, epithelial cells contribute to innate immunity via the
local secretion of inflammatory cytokines. These are directly produced by infected cells or by …

Given the evolutionary importance of gene duplication to the emergence of species-specific
traits, we have extended the application of cDNA array-based comparative genomic …

Reliable prediction of free energy changes upon amino acid substitutions (ΔΔ G s) is crucial
to investigate their impact on protein stability and protein–protein interaction. Advances in …