Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …

Myeloid cell leukemia sequence 1 (MCL-1) is an antiapoptotic protein that plays a key role in
promoting cell survival in multiple myeloma (MM), acute myeloid leukemia (AML), and non …

Mitochondrial energetics and respiration have emerged as important factors in how cancer
cells respond to or evade apoptotic signals. The study of the functional connection between …

Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …

Malignant melanoma is one of the most difficult cancers to treat due to its resistance to
chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint …

Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …

It has been widely accepted that mitochondria-dependent apoptosis initiates when select
BH3-only proteins (BID, BIM, etc.) directly engage and allosterically activate effector proteins …

Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-
regulation of the balance between proliferation and apoptosis contributes to tumor initiation …

Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention
in the last decade as potential targeted cancer therapies. However, little is known about the …