The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

Nuclear proteins are often given a concise title that captures their function, such as
'transcription factor,''polymerase'or 'nuclear-receptor.'However, for members of the …

The presence of actin and nuclear myosin I (NMI) in the nucleus suggests a role for these
motor proteins in nuclear functions. We have investigated the role of actin and nuclear …

Actin is abundant in the nucleus and has been implicated in transcription; however, the
nature of this involvement has not been established. Here we demonstrate that β-actin is …

The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …

β-Actin, once thought to be an exclusively cytoplasmic protein, is now known to have
important functions within the nucleus. Nuclear β-actin associates with and functions in …

While actin was discovered in the nucleus over 50 years ago, research lagged for decades
due to strong skepticism. The revitalization of research into nuclear actin occurred after it …

When transcription from the human U6 snRNA gene is reconstituted with recombinant
factors and purified RNA polymerase III (pol III), pol III must be treated with CK2 to be active …

To determine the role of actin–ribonucleoprotein complexes in transcription, we set out to
identify novel actin-binding proteins associated with RNA polymerase II (Pol II). Using affinity …