Current developments of coumarin-based anti-cancer agents in medicinal chemistry
S Emami, S Dadashpour - European Journal of Medicinal Chemistry, 2015 - Elsevier
Cancer is one of the leading health hazards and the prominent cause of death in the world.
A number of anticancer agents are currently in clinical practice and used for treatment of …
A number of anticancer agents are currently in clinical practice and used for treatment of …
[HTML][HTML] Hydrazide–hydrazones as potential antimicrobial agents: overview of the literature since 2010
Ł Popiołek - Medicinal Chemistry Research, 2017 - Springer
Hydrazide–hydrazone derivatives are present in many bioactive molecules and display a
wide variety of biological activities, such as antibacterial, antitubercular, antifungal …
wide variety of biological activities, such as antibacterial, antitubercular, antifungal …
Investigation into antiproliferative activity and apoptosis mechanism of new arene Ru (ii) carbazole-based hydrazone complexes
Ruthenium complexes with bioactive ligands are becoming promising substitutes for
platinum complexes due to their precise action against various cancers. In the present study …
platinum complexes due to their precise action against various cancers. In the present study …
Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives
Drug resistance is a major impediment for cancer treatment, to overcome it we designed and
synthesized sixteen coumarins bearing hydrazide–hydrazone moiety and evaluated them …
synthesized sixteen coumarins bearing hydrazide–hydrazone moiety and evaluated them …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids
Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
[HTML][HTML] A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization
O Ebenezer, M Shapi, JA Tuszynski - International Journal of Molecular …, 2022 - mdpi.com
Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …
Designing of novel zinc (II) Schiff base complexes having acyl hydrazone linkage: study of phosphatase and anti-cancer activities
Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were
prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2 …
prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2 …
Design, synthesis, molecular docking, in silico ADMET profile and anticancer evaluations of sulfonamide endowed with hydrazone-coupled derivatives as VEGFR-2 …
AM Sayed, FA Taher, MRK Abdel-Samad… - Bioorganic …, 2021 - Elsevier
A new series of sulfonamide endowed with hydrazone coupled to dimethyl and/or diethyl
malonates were prepared. Various sulfa drugs were diazotized and followed by coupling …
malonates were prepared. Various sulfa drugs were diazotized and followed by coupling …
Synthesis, antiproliferative and apoptosis induction potential activities of novel bis (indolyl) hydrazide-hydrazone derivatives
In recent years, indole-indazolyl hydrazide-hydrazone derivatives with strong cell growth
inhibition and apoptosis induction characteristics are being strongly screened for their …
inhibition and apoptosis induction characteristics are being strongly screened for their …
A comprehensive review of N-heterocycles as cytotoxic agents
D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …