Cancer is one of the leading health hazards and the prominent cause of death in the world.
A number of anticancer agents are currently in clinical practice and used for treatment of …

Hydrazide–hydrazone derivatives are present in many bioactive molecules and display a
wide variety of biological activities, such as antibacterial, antitubercular, antifungal …

Ruthenium complexes with bioactive ligands are becoming promising substitutes for
platinum complexes due to their precise action against various cancers. In the present study …

Drug resistance is a major impediment for cancer treatment, to overcome it we designed and
synthesized sixteen coumarins bearing hydrazide–hydrazone moiety and evaluated them …

Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were
prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2 …

A new series of sulfonamide endowed with hydrazone coupled to dimethyl and/or diethyl
malonates were prepared. Various sulfa drugs were diazotized and followed by coupling …

In recent years, indole-indazolyl hydrazide-hydrazone derivatives with strong cell growth
inhibition and apoptosis induction characteristics are being strongly screened for their …

Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …