In the last 10 years, extended-spectrum β-lactamase-producing enterobacteria (ESBL-E)
have become one of the main challenges for antibiotic treatment of enterobacterial …

Many studies report the high prevalence of multiply drug-resistant (MDR) strains. Because
MDR infections are often significantly harder and more expensive to treat, they represent a …

Within a susceptible wild-type population, a small fraction of cells, even< 10− 9, is not
affected when challenged by an antimicrobial agent. This subpopulation has mutations that …

This review will consider the gut as a reservoir for antimicrobial resistance, colonization
resistance, and how disruption of the microbiome can lead to colonization by pathogenic …

Escherichia coli sequence type 131 (ST131) is an extensively antimicrobial-resistant E. coli
clonal group that has spread explosively throughout the world. Recent molecular …

Whilst augmented renal clearance (ARC) is associated with reduced β-lactam plasma
concentrations, its impact on clinical outcomes is unclear. This single-centre prospective …

Background Antibiotics are life-saving drugs but severely affect the gut microbiome with
short-term consequences including diarrhea and selection of antibiotic-resistant bacteria …

Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As
with other such assets, keeping it available requires both conservation and innovation …

After two decades of the discovery of plasmid-mediated quinolone resistance (PMQR), three
different mechanisms have been associated to this phenomenon: target protection (Qnr …

Microbial infections are a life threatening concern in several areas, which include the
biomedical sector, healthcare products, water purification systems, and food packaging …