Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

The rational design of highly oriented and integrated heterostructures based on metal–
organic framework (MOF)-derived carbon containing n-type metal chalcogenides (Zn–In …

Obesity promotes diverse pathologies, including atherosclerosis and dementia, which
frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has …

Members of the NSL histone acetyltransferase complex are involved in multiorgan
developmental syndromes. While the NSL complex is known for its importance in early …

Reversible acetylation of mitochondrial proteins is a regulatory mechanism central to
adaptive metabolic responses. Yet, how such functionally relevant protein acetylation is …

Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive
molecule involved in the regulation of many cellular processes. One of the most prominent …

Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous
work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators …

Histone acetylation is highly conserved across eukaryotes and has been linked to gene
activation since its discovery nearly 60 years ago. Over the past decades, histone …

Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they
support vasculature functioning, participate in tissue regeneration, and regulate blood flow …