Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

Inflammation is the most common feature of many chronic diseases and complications, while
playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 …

Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …

Abstract Coronavirus disease-19 (COVID-19), a devastating respiratory illness caused by
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …