High-speed atomic force microscopy (HS-AFM) is now materialized. It allows direct
visualization of dynamic structural changes and dynamic processes of functioning biological …

Directly observing individual protein molecules in action at high spatiotemporal resolution
has long been a holy grail for biological science. This is because we long have had to infer …

Vinculin is an actin-binding protein thought to reinforce cell-cell and cell-matrix adhesions.
However, how mechanical load affects the vinculin–F-actin bond is unclear. Using a single …

The dynamic behaviour of myosin V molecules translocating along actin filaments has been
mainly studied by optical microscopy. The processive hand-over-hand movement coupled …

Individual molecular motors, or motor proteins, are enzymatic molecules that convert
chemical energy, typically obtained from the hydrolysis of ATP (adenosine triphosphate) …

The general structural features of the motor region of myosin superfamily members are now
well established, as is a subset of the structural and kinetic transitions of the actin-myosin …

Cells use molecular motors, such as myosins, to move, position and segregate their
organelles. Class V myosins possess biochemical and structural properties that should …

In the history of science and technology, researchers have always undertaken endeavors to
enhance the degree of “directness of measurement”. With “directness of measurement”, we …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Cytoplasmic dynein is responsible for many aspects of cellular and subcellular movement.
LIS1, NudE, and NudEL are dynein interactors initially implicated in brain developmental …