The ability of the skin to repair itself after injury is vital to human survival and is disrupted in a
spectrum of disorders. The process of cutaneous wound healing is complex, requiring a …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

Human skin uses millions of hairs and glands distributed across the body surface to function
as an external barrier, thermoregulator and stimuli sensor. The large-scale generation of …

Recessive dystrophic epidermolysis bullosa (RDEB) is characterized by a functional deficit
of type VII collagen protein due to gene defects in the type VII collagen gene (COL7A1) …

Embryonic stem cells (ESCs) have an unlimited proliferative capacity and extensive
differentiation capability. They are an alternative source for regenerative therapies with a …

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disorder
caused by mutations in the COL7A1 gene encoding type VII collagen (C7). The spectrum of …

Although development leads unidirectionally toward more restricted cell fates, recent work in
cellular reprogramming has proven that one cellular identity can strikingly convert into …

The elderly constitute the age group most susceptible to wound healing disorders and
chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic …

Many diseases, as well as side effects of drugs, manifest themselves through skin
symptoms. Skin is a complex tissue that hosts various specialized cell types and performs …