Heart failure (HF) is a rapidly growing public health issue with an estimated prevalence of 64
million people globally. Although the incidence of HF has stabilised worldwide and seems to …

Natriuretic peptide [NP; B‐type NP (BNP), N‐terminal proBNP (NT‐proBNP), and
midregional proANP (MR‐proANP)] concentrations are quantitative plasma biomarkers for …

Background: The gut microbiota-dependent metabolite phenylacetylgutamine (PAGln) is
both associated with atherothrombotic heart disease in humans, and mechanistically linked …

As the prevalence of obesity continues to grow worldwide, the health and financial burden of
obesity-related comorbidities grows too. Cardiovascular disease (CVD) is clearly associated …

Supercentenarians (those aged≥ 110 years) are approaching the current human longevity
limit by preventing or surviving major illness. Identifying specific biomarkers conducive to …

BACKGROUND In aging populations, cardiovascular disease (CVD) and frailty are common
and often coexist. It is possible that common risk factors and pathophysiological pathways …

Background: NPs (natriuretic peptides) are cardiac-derived hormones that promote
natriuresis, diuresis, and vasodilation. Preclinical evidence suggests that nonhemodynamic …

Background The prevalence of cardiovascular disease (CVD) has been continuously
increasing, and this trend is projected to continue. CVD is rapidly becoming a significant …

Regular exercise leads to widespread salutary effects, and there is increasing recognition
that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited …

Background Inflammation may contribute to incident heart failure (HF). Rheumatoid arthritis
(RA), a prototypic inflammatory condition, may serve as a model for understanding …