At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

Until recently, trophoblast invasion during human placentation was characterized by and
restricted to invasion into uterine connective tissues and the uterine spiral arteries. The latter …

The release of extracellular vesicles (EV) by the syncytiotrophoblast (STB) may be an
important mechanism by which the placenta signals to the mother. STB derived EV (STBEV) …

Extracellular vesicles (EVs) are membrane-bound complexes secreted from cells under both
physiological and pathological conditions. They contain proteins, nucleic acids and lipids …

The semiallogenic fetus is tolerated by the maternal immune system through control of
innate and adaptive immune responses. Trophoblast cells secrete nanometer scale …

Extracellular vesicles (EVs) are membrane-bound vesicles released into the extracellular
space by almost all types of cells. EVs can cross the physiological barriers, and a variety of …

The cardinal manifestations of the pregnancy-specific disorder preeclampsia, new-onset
hypertension, and proteinuria that resolve with placental delivery have been linked to an …

Preeclampsia is a hypertensive disease that complicates many pregnancies, typically
presenting with new-onset or worsening hypertension and proteinuria. It is well recognized …

Proper development of the placenta is vital for pregnancy success. The placenta regulates
exchange of nutrients and gases between maternal and fetal blood and produces hormones …

Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and
underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the …