Physiological processes are mainly controlled by intermolecular recognition mechanisms
involving protein–protein and protein–ligand (low molecular weight molecules) interactions …

Saturation transfer difference NMR (STD NMR) spectroscopy is one of the most powerful
NMR techniques for detection and characterization of transient (fast) receptor–ligand …

Molecular recognition is at the base of all biological events and its knowledge at atomic level
is pivotal in the development of new drug design approaches. NMR spectroscopy is one of …

Highlights•GTs are highly selective in nature.•Structural snapshots provided insights into the
catalytic mechanisms of GTs.•GTs have evolved a series of mechanisms to gain functionality …

Bacterial Ser/Thr kinases modulate a wide number of cellular processes. In Bacillus subtilis,
the Ser/Thr kinase PrkC has been shown to induce germination of bacterial spores in …

Bacterial glycosyltransferases (GT) often synthesize the same glycan linkages as
mammalian GT; yet, they usually have very little sequence identity. Nevertheless, enzymatic …

The development of antibodies that target specific glycan structures on cancer cells or
human pathogens poses a significant challenge due to the immense complexity of naturally …

The enzymatic mechanism by which retaining glycosyltransferases (GTs) transfer
monosaccharides with net retention of the anomeric configuration has, so far, resisted …

The final step in the enzymatic synthesis of the ABO (H) blood group A and B antigens is
catalyzed by two closely related glycosyltransferases, an α-(1→ 3)-N …

Glycan–protein interactions are highly specific yet transient, rendering glycans ideal
recognition signals in a variety of biological processes. In human norovirus (HuNoV) …