Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

The twin epidemic of obesity and diabetes is a major crisis globally. Several epidemiologic
studies reveal the parallel escalation of obesity and diabetes. The term 'diabesity'expresses …

The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH)
releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and …

Leptin and ghrelin are two hormones that have been recognized to have a major influence
on energy balance. Leptin is a mediator of long‐term regulation of energy balance …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Ghrelin is a 28 amino acid, appetite-stimulating peptide hormone secreted by the food-
deprived stomach. Serine-3 of ghrelin is acylated with an eight-carbon fatty acid, octanoate …

Food intake, energy expenditure and body adiposity are homeostatically regulated. Central
and peripheral signals communicate information about the current state of energy balance to …

Appetite is regulated by a complex system of central and peripheral signals which interact in
order to modulate the individual response to nutrient ingestion. Peripheral regulation …