Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives
We have synthesized a series of benzimidazole bearing thiazolidinone derivatives (1-20),
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
[HTML][HTML] Microbial multienzyme viz., pectinase, cellulase and amylase production using fruit and vegetable waste as substrate—a review
Around 70 million metric tonnes of fruit and vegetable waste (FVW) are produced each year
and are eventually discarded as wholesale garbage. Microorganisms decompose this FVW …
and are eventually discarded as wholesale garbage. Microorganisms decompose this FVW …
New thiazole-based thiazolidinone derivatives: synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
A series of thiazole-based thiazolidinone derivatives (1-20) have been synthesized and
evaluated against α-glucosidase and α-amylase enzymes. All derivatives showed good α …
evaluated against α-glucosidase and α-amylase enzymes. All derivatives showed good α …
Benzimidazole bearing thiosemicarbazone derivatives act as potent α-amylase and α-glucosidase inhibitors; synthesis, bioactivity screening and molecular docking …
Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our
research group has synthesized and evaluated libraries of heterocyclic analogs against α …
research group has synthesized and evaluated libraries of heterocyclic analogs against α …
New oxadiazole bearing thiosemicarbazide analogues: Synthesis, anti-alzheimer inhibitory potential and their molecular docking study
Synthesized oxadiazole-bearing thiosemicarbazide analogues (1–14) were characterized
by NMR and HR-EIMS and were tested against acetylcholinesterase and …
by NMR and HR-EIMS and were tested against acetylcholinesterase and …
Novel N-Acyl Hydrazone Compounds as Promising Anticancer Agents: Synthesis and Molecular Docking Studies
Y Biliz, B Hasdemir, H Başpınar Küçük… - ACS …, 2023 - ACS Publications
In this study, a new series of N-acyl hydrazones 7a-e, 8a-e, and 9a-e, starting from methyl δ-
oxo pentanoate with different substituted groups 1a-e, were synthesized as anticancer …
oxo pentanoate with different substituted groups 1a-e, were synthesized as anticancer …
Synthesis, molecular docking study of thiazole derivatives and exploring their dual inhibitor potentials against α-amylase and α-glucosidase
Diabetes mellitus is one of the most chronic metabolic diseases. The current study
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
New 4-(arylidene) amino-1, 2, 4-traizole-5-thiol derivatives and their acyclo thioglycosides as α-glucosidase and α-amylase inhibitors: Design, synthesis, and …
H El Sayed, MMK Farahat, LF Awad, M Balbaa… - Journal of Molecular …, 2022 - Elsevier
Abstract A series of 1, 2, 4-triazole Schiffs bases 3-9 and their respective acyclo
thioglycosides 10-15 based α-glucosidase and α-amylase inhibitors were synthesized under …
thioglycosides 10-15 based α-glucosidase and α-amylase inhibitors were synthesized under …