The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …

The cilium, once considered a vestigial structure, is a conserved, microtubule-based
organelle critical for transducing extracellular chemical and mechanical signals that control …

Neurons are terminally differentiated cells that use their microtubule arrays not for cell
division but rather as architectural elements required for the elaboration of elongated axons …

Tubulin and microtubules are subject to a remarkable number of post-translational
modifications. Understanding the roles these modifications play in determining the functions …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Tubulin posttranslational modifications have been predicted to control cytoskeletal functions
by coordinating the molecular interactions between microtubules and their associating …

In the developing brain, dendrite branches and dendritic spines form and turn over
dynamically. By contrast, most dendrite arbors and dendritic spines in the adult brain are …

Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …

Microtubule-severing enzymes are critical for the biogenesis and maintenance of complex
microtubule arrays in axons, spindles, and cilia where tubulin detyrosination, acetylation …