Insulin and insulin-like growth factors (IGFs) are well known as key regulators of energy
metabolism and growth. There is now considerable evidence that these hormones and the …

Background: Bisphenol A (BPA) is an endocrine disrupting chemical widely used in the
manufacture of polycarbonate plastic and epoxy resin to produce a multitude of consumer …

Neural stem cells (NSCs) are found in two regions in the adult brain: the subgranular zone
(SGZ) in the hippocampal dentate gyrus and the subventricular zone (SVZ) adjacent to the …

Determining the mechanism of gene function is greatly enhanced using conditional
mutagenesis. However, generating engineered conditional alleles is inefficient and has only …

Diabetes mellitus (DM) affects over 10% of the world's population. Hyperglycemia is the
main feature for the diagnosis of this disease. The zebrafish (Danio rerio) is an established …

Since its introduction as a genetic vertebrate model system approximately 30 years ago, the
focus of zebrafish research has increasingly shifted to questions that are also relevant for …

Müller glia (MG) in the zebrafish retina respond to retinal injury by generating multipotent
progenitors for retinal repair. Here, we show that Insulin, Igf-1, and fibroblast growth factor …

Bisphenol A (BPA) is an endocrine disruptor used in manufacturing of plastic devices,
resulting in an ubiquitous presence in the environment linked to human infertility, obesity or …

Fish have provided essential information about the structure, biosynthesis, evolution, and
function of insulin (INS) as well as about the structure, evolution, and mechanism of action of …

Hypoxic microenvironment supports cancer stem cell survival, causes poor response to
anticancer therapy and tumor recurrence. Inhibition of Notch-1 signaling in adenocarcinoma …