Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

E Choy - Rheumatology, 2012 - academic.oup.com
RA is a progressive inflammatory autoimmune disease with articular and systemic effects. Its
exact cause is unknown, but genetic and environmental factors are contributory. T cells, B …

EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis

MJL Peters, DPM Symmons, D McCarey… - Annals of the …, 2010 - ard.bmj.com
Objectives: To develop evidence-based EULAR recommendations for cardiovascular (CV)
risk management in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and …

Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

SE Gabriel, K Michaud - Arthritis research & therapy, 2009 - Springer
Epidemiology is the study of the distribution and determinants of disease in human
populations. Over the past decade there has been considerable progress in our …

The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis

GJ Tobón, P Youinou, A Saraux - Autoimmunity reviews, 2010 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by a
distinctive pattern of bone and joint destruction. RA patients have an increased risk of death …

Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies

M Elhai, C Meune, J Avouac, A Kahan… - Rheumatology, 2012 - academic.oup.com
Objective. SSc is known as the most severe connective tissue disorder, and to be associated
with a high mortality risk. Some improvements in therapy for SSc have been achieved in …

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results …

P Emery, E Keystone, HP Tony, A Cantagrel… - Annals of the …, 2008 - ard.bmj.com
Objectives: The phase III RADIATE study examined the efficacy and safety of tocilizumab, an
anti-IL-6 receptor monoclonal antibody in patients with rheumatoid arthritis (RA) refractory to …

[HTML][HTML] Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNFα inhibitors and rituximab

J Listing, J Kekow, B Manger, GR Burmester… - Annals of the …, 2015 - ard.bmj.com
Objectives To investigate the impact of disease activity, the course of the disease, its
treatment over time, comorbidities and traditional risk factors on survival. Methods Data of …

Cardiovascular effects of approved drugs for rheumatoid arthritis

F Atzeni, J Rodríguez-Carrio, CD Popa… - Nature Reviews …, 2021 - nature.com
The risk of cardiovascular disease is increased in patients with rheumatoid arthritis
compared with the general population owing to the influence of traditional and non …

Safety and efficacy of tofacitinib, an oral Janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studies

J Wollenhaupt, J Silverfield, EB Lee, JR Curtis… - The Journal of …, 2014 - jrheum.org
Objective. To describe the longterm safety and efficacy profile of tofacitinib in patients with
moderate to severe active rheumatoid arthritis (RA). Methods. Data were pooled from 2 open …

Cardiovascular co-morbidity in patients with rheumatoid arthritis: a narrative review of risk factors, cardiovascular risk assessment and treatment

A Jagpal, I Navarro-Millán - BMC rheumatology, 2018 - Springer
Cardiovascular disease (CVD) is markedly increased in patients with rheumatoid arthritis
partly due to accelerated atherosclerosis from chronic inflammation. Traditional …