Brugada syndrome and reduced right ventricular outflow tract conduction reserve: a final common pathway?
ER Behr, Y Ben-Haim, MJ Ackerman… - European heart …, 2021 - academic.oup.com
Brugada syndrome (BrS) was first described as a primary electrical disorder predisposing to
the risk of sudden cardiac death and characterized by right precordial lead ST elevation …
the risk of sudden cardiac death and characterized by right precordial lead ST elevation …
SCN5A channelopathy: arrhythmia, cardiomyopathy, epilepsy and beyond
CA Remme - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …
for proper electrical conduction within the heart. Both acquired conditions associated with …
International evidence based reappraisal of genes associated with arrhythmogenic right ventricular cardiomyopathy using the clinical genome resource framework
CA James, JDH Jongbloed… - Circulation: Genomic …, 2021 - Am Heart Assoc
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited
disease characterized by ventricular arrhythmias and progressive ventricular dysfunction …
disease characterized by ventricular arrhythmias and progressive ventricular dysfunction …
Brugada syndrome genetics is associated with phenotype severity
G Ciconte, MM Monasky, V Santinelli… - European heart …, 2021 - academic.oup.com
Abstract Aims Brugada syndrome (BrS) is associated with an increased risk of sudden
cardiac death due to ventricular tachycardia/fibrillation (VT/VF) in young, otherwise healthy …
cardiac death due to ventricular tachycardia/fibrillation (VT/VF) in young, otherwise healthy …
Subepicardial cardiomyopathy: a disease underlying J-wave syndromes and idiopathic ventricular fibrillation
C Miles, BJ Boukens, C Scrocco, AAM Wilde… - Circulation, 2023 - Am Heart Assoc
Brugada syndrome (BrS), early repolarization syndrome (ERS), and idiopathic ventricular
fibrillation (iVF) have long been considered primary electrical disorders associated with …
fibrillation (iVF) have long been considered primary electrical disorders associated with …
Arrhythmias as presentation of genetic cardiomyopathy
J Lukas Laws, MC Lancaster… - Circulation …, 2022 - Am Heart Assoc
There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …
The genetics of Brugada syndrome
M Cerrone, S Costa, M Delmar - Annual review of genomics and …, 2022 - annualreviews.org
Brugada syndrome is a heritable channelopathy characterized by a peculiar
electrocardiogram (ECG) pattern and increased risk of cardiac arrhythmias and sudden …
electrocardiogram (ECG) pattern and increased risk of cardiac arrhythmias and sudden …
Prognostic value of nonischemic ringlike left ventricular scar in patients with apparently idiopathic nonsustained ventricular arrhythmias
Background: Left ventricular (LV) scar on late gadolinium enhancement (LGE) cardiac
magnetic resonance has been correlated with life-threatening arrhythmic events in patients …
magnetic resonance has been correlated with life-threatening arrhythmic events in patients …
Subcellular diversity of Nav1. 5 in cardiomyocytes: distinct functions, mechanisms and targets
GA Marchal, CA Remme - The Journal of Physiology, 2023 - Wiley Online Library
In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α‐
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …
Loss of nuclear envelope integrity and increased oxidant production cause DNA damage in adult hearts deficient in PKP2: a molecular substrate of ARVC
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by
high propensity to life-threatening arrhythmias and progressive loss of heart muscle. More …
high propensity to life-threatening arrhythmias and progressive loss of heart muscle. More …