Cells and tissues can sense and react to the modifications of the physico-chemical
properties of the extracellular environment (ECM) through integrin-based adhesion sites and …

Transduction of mechanical forces and chemical signals affect every cell in the human body.
Fluid flow in systems such as the lymphatic or circulatory systems modulates not only cell …

In the body, soft tissues often undergo cycles of stretching and relaxation that may affect cell
behaviour without changing matrix rigidity. To determine whether transient forces can …

Amniogenesis—the development of amnion—is a critical developmental milestone for early
human embryogenesis and successful pregnancy,. However, human amniogenesis is …

Cells within the human body are subjected to continuous, cyclic mechanical strain caused
by various organ functions, movement, and growth. Cells are well known to have the ability …

Precise reconstruction of heterotypic cell–cell interactions in vitro requires the coculture of
different cell types in a highly controlled manner. In this article, we report a standing surface …

The extracellular matrix (ECM) provides structural and biochemical support to cells within
tissues. An emerging body of evidence has established that the ECM plays a key role in cell …

The human circulatory system is a marvelous fluidic system, which is very sensitive to
biophysical and biochemical cues. The current animal and cell culture models do not …

The rate of the remodeling of the arterialized saphenous vein conduit limits the outcomes of
coronary artery bypass graft surgery (CABG), which may be influenced by endothelial …

Microelectromechanical systems (MEMS) and micro total analysis systems (μTAS)
revolutionized the biochemical and electronic industries, and this miniaturization process …