Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

While most of current models investigating bone remodelling are based on matrix
deformation, intramedullary pressure also plays a role. Bone remodelling is orchestrated by …

Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical
environment of bone cells and may thereby initiate a mechanobiological response. It has …

The use of mechanical biology and biomechanical signal transduction is a novel approach
to attenuate biological tissue degeneration, whereas the understanding of specific cellular …

Distribution of intramedullary pressure (ImP) induced bone fluid flow has been suggested to
influence the magnitude of mechanotransductory signals within bone. As osteocytes have …

Perlecan, a heparan sulfate proteoglycan, acts as a mechanical sensor for bone to detect
external loading. Deficiency of perlecan increases the risk of osteoporosis in patients with …

The microcirculation of bone and marrow is vital for bone development, maintenance, and
repair. In addition to the well-known function of transporting oxygen, nutrients, systemic …

The skeleton is highly vascularized due to the various roles blood vessels play in the
homeostasis of bone and marrow. For example, blood vessels provide nutrients, remove …

The biological effect of ultrasound on bone regeneration has been well documented, yet the
underlying mechanotransduction mechanism is largely unknown. In relation to the …

This chapter presents an in silico study to compare the osteogenic potentials of normal strain-
derived strain energy density (SED) and fluid shear. In vivo studies reported that mechanical …